Why the study?
Easily implementable guidelines for individual risk stratification and decision-making to identify patients unlikely to benefit from ICD pulse generator exchange are lacking.
Does CRT-D pulse generator exchange or upgrade carry a higher risk of 1-year mortality compared to ICD exchange, and what are the independent predictors of mortality?
Cohort (n=588)
No
Does CRT-D pulse generator exchange or upgrade carry a higher risk of 1-year mortality compared to ICD exchange, and what are the independent predictors of mortality?
Absolute Event Rate: 10.6% vs 2.8%
p-value: p=0.002
One-year mortality after CRT-D replacement or upgrade remains considerable (10.6%), with LVEF ≤30%, NYHA class ≥3, severe renal dysfunction, and anemia independently predicting death.
Implantable cardioverter defibrillators (ICDs) significantly contribute to the prevention of sudden cardiac death in selected patients. However, it is essential to identify those who are likely to not have benefit from an ICD and to defer a pulse generator exchange. Easily implementable guidelines for individual risk stratification and decision making are lacking. This study investigates the 1-year mortality of patients who underwent an ICD or cardiac resynchronization therapy with defibrillator function (CRT-D) pulse generator replacement in a contemporary real-world tertiary hospital setting. The cause of death and patient- and procedure-related factors are stratified, and predictive values for 1-year mortality are evaluated. Patients with a follow-up of ≥365 days (or prior mortality) after an ICD or CRT-D exchange at the Leiden University Medical Center from 1 January 2018 until 31 December 2021 were eligible. In total, 588 patients were included (77% male, 69 [60–76] years old, 59% primary prevention, 46% ischemic cardiomyopathy and 37% mildly reduced left ventricular ejection fraction (LVEF)). Patients undergoing a CRT-D replacement or upgrade had a significantly higher 1-year all-cause mortality (10.7% and 11.9%, respectively) compared to patients undergoing ICD (2.8%) exchange (p = 0.002). LVEF ≤ 30%, New York Heart Association class ≥ 3, estimated glomerular filtration rate ≤ 30 mL/min/m2 and haemoglobin ≤ 7 mmol/L were independently associated with mortality within 1 year after pulse generator replacement. There is a growing need for prospectively validated risk scores to weight individualized risk of mortality with the expected ICD therapy benefit and to support a well-informed, shared decision-making process.
No takes yet. Share an insight, caveat, or question.
Feijen et al. (2023) conducted a cohort in Patients undergoing ICD or CRT-D pulse generator replacement or upgrade (n=588). CRT-D pulse generator replacement and/or upgrade vs. ICD pulse generator exchange was evaluated on 1-year all-cause mortality (p=0.002).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: