Key result
High salt activates the central nervous system aldosterone-endogenous ouabain pathway in hypertensive rat models, and salt-induced hypertension can be prevented by specific CNS blockade.
Population
Hypertension models including Dahl S rats and spontaneous hypertensive rats
Design
Review
Authors
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Hypothesis-generating for CNS aldosterone-ouabain blockade in salt-sensitive hypertension; leaves open translation to human therapy.
Central neuromodulatory pathways, particularly the aldosterone-endogenous ouabain pathway, play a key role in salt-induced hypertension and represent potential targets for modulating chronic sympathetic hyperactivity.
Gabor et al. (2012) conducted a review in Hypertension. Central neuromodulatory pathways (aldosterone-endogenous ouabain pathway) was evaluated. High salt activates the central nervous system aldosterone-endogenous ouabain pathway in hypertensive rat models, and salt-induced hypertension can be prevented by specific CNS blockade.
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