Key result
The DASH diet significantly lowered 24-hour ambulatory systolic blood pressure by 4.6 mm Hg and diastolic blood pressure by 2.8 mm Hg compared with the control diet.
RCT (n=357)
Randomized
Yes
Proposes a linear mixed model with orthonormal polynomials to improve the analysis of subject-specific trajectories in 24-hour ambulatory blood pressure monitoring data.
Answers are grounded in this paper and cite their sources.
DASH diet was associated with lower ambulatory BP; leaves open whether the proposed mixed model improves ABPM trajectory analysis.
The use of 24-hour ambulatory blood pressure monitoring (ABPM) in clinical practice and observational epidemiological studies has grown considerably in the past 25 years. ABPM is a very effective technique for assessing biological, environmental, and drug effects on blood pressure. In order to enhance the effectiveness of ABPM for clinical and observational research studies via analytical and graphical results, developing alternative data analysis approaches are important. The linear mixed model for the analysis of longitudinal data is particularly well-suited for the estimation of, inference about, and interpretation of both population and subject-specific trajectories for ABPM data. Subject-specific trajectories are of great importance in ABPM studies, especially in clinical research, but little emphasis has been placed on this dimension of the problem in the statistical analyses of the data. We propose using a linear mixed model with orthonormal polynomials across time in both the fixed and random effects to analyze ABPM data. Orthonormal polynomials in the linear mixed model may be used to develop model-based, subject-specific 24-hour ABPM correlates of cardiovascular disease outcomes. We demonstrate the proposed analysis technique using data from the Dietary Approaches to Stop Hypertension (DASH) study, a multicenter, randomized, parallel arm feeding study that tested the effects of dietary patterns on blood pressure.
No takes yet. Share an insight, caveat, or question.
Edwards et al. (2010) conducted an RCT in Elevated blood pressure (n=357). DASH diet vs. Control diet was evaluated on Change in 24-hour ambulatory systolic blood pressure (p=<0.0001). The DASH diet significantly lowered 24-hour ambulatory systolic blood pressure by 4.6 mm Hg and diastolic blood pressure by 2.8 mm Hg compared with the control diet.
Synapse has enriched 10 related papers. Consider them for comparative context: