Key result
Declining LVEF correlates with increased MMP-9 and decreased TIMP-1 gene expression in CAD patients.
Why the study?
Coronary artery disease is the most common cause of heart failure, warranting evaluation of MMP-9 and TIMP-1 gene transcriptional activity as potential diagnostic and prognostic markers.
Does the transcriptional activity of MMP-9 and TIMP-1 genes correlate with the presence and severity of heart failure due to coronary artery disease?
Cross-Sectional (n=150)
No
Does the transcriptional activity of MMP-9 and TIMP-1 genes correlate with the presence and severity of heart failure due to coronary artery disease?
p-value: p=<0.05
MMP-9 and TIMP-1 transcriptional activities in peripheral blood mononuclear cells show potential as molecular biomarkers for diagnosing and tracking the progression of heart failure in ischemic heart disease.
MMP-9 upregulation with TIMP-1 downregulation associates with declining LVEF in ischemic HF; hypothesis-generating for biomarkers, pending prospective validation.
The most common cause of heart failure (HF) is coronary artery disease (CAD). The aim of this study was to evaluate the transcriptional activity of the metalloproteinase 9 (MMP-9) and tissue metalloproteinase inhibitor 1 (TIMP-1) genes in a study group of patients with HF due to CAD and in the control group, as well as assess the transcriptional activity of the examined genes, taking into account the number of affected coronary arteries and the severity of heart failure. The study group consisted of a total of 150 (100%) patients. The material for the study was peripheral blood, and molecular tests were performed using the quantitative QRT-PCR technique. The transcriptional activity of the MMP-9 gene was significantly higher in the group of patients with CAD and HF. It was also significantly higher with the progression of heart failure. TIMP-1 gene transcriptional activity was significantly lower with the advancement of heart failure. The transcriptional activity of the MMP-9 and TIMP-1 genes differentiated the examined patients. The severity of HF, and a significant increase in the QRT-PCR transcriptional activity of the MMP-9 gene with a simultaneous decrease in the activity of the TIMP-1 gene, makes them useful diagnostic and prognostic markers in clinical practice.
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Korzeń et al. (2023) conducted a cross-sectional in Heart Failure due to Coronary Artery Disease (n=150). Heart failure and its severity due to coronary artery disease vs. Patients with coronary artery disease without heart failure, and patients with coronary artery disease excluded was evaluated on Transcriptional activity of the MMP-9 and TIMP-1 genes in peripheral blood mononuclear cells (p=<0.05). The transcriptional activity of the MMP-9 gene significantly increased, while TIMP-1 activity significantly decreased, with the advancement of heart failure severity as measured by decreasing left ventricular ejection fraction.
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