Key result
TGF-β1 -913G/C variant linked to ~32% higher risk of MI vs CC genotype.
Why the study?
Because TGF-β1 contributes to angiotensin II-mediated collagen accumulation after myocardial infarction, researchers investigated the association between genetic variants of the TGF-β1 gene and MI risk.
Does the TGF-β1 -913G/C polymorphism increase the risk of myocardial infarction in a Chinese Han population?
Case-Control (n=1,181)
Yes
Does the TGF-β1 -913G/C polymorphism increase the risk of myocardial infarction in a Chinese Han population?
Odds Ratio: 1.32 (95% CI 1.04–1.68)
p-value: p=0.025
The TGF-β1 -913G/C polymorphism is a potential genetic risk factor and prognostic biomarker for myocardial infarction in the Chinese Han population.
Supports TGF-β1 genotyping research in Chinese Han; leaves open prospective validation before any clinical risk stratification.
Transforming growth factor (TGF)-β1 contributed to angiotensin II (Ang II)-mediated collagen accumulation after myocardial infarction (MI). The present study aimed to investigate the association of genetic variant of TGF-β1 gene with the risk of MI. The present study recruited a total of 530 MI patients and 651 healthy controls. The genomic DNA was extracted and subjected into polymerase chain reaction (PCR) and Sanger sequencing. The present study indicated that TGF-β1 -913G/C polymorphism was associated with increased risk for MI under the co-dominant, dominant and allelic models. The increased risk effect was also evident among the females, younger subjects (age < 60 years), smokers, non-drinkers and individuals with hypertension. Additionally, the present study observed significant differences among cases and controls in terms of total cholesterol (TC). In conclusion, TGF-β1 -913G/C polymorphism is associated with increased risk for MI. TGF-β1 -913G/C polymorphism may be a potential prognostic biomarker for MI.
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Wu et al. (2019) conducted a case-control in Myocardial Infarction (n=1,181). TGF-β1 -913G/C polymorphism vs. CC genotype was evaluated on Risk of myocardial infarction (CT+TT vs CC genotype) (OR 1.32, 95% CI 1.04-1.68, p=0.025). The TGF-β1 -913G/C polymorphism (CT+TT genotype) was associated with a significantly increased risk of myocardial infarction compared to the CC genotype (OR 1.32).
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