Key result
Carrying the TGFB1*-509T allele is linked to ~45% higher risk of MI.
Why the study?
The role of TGFB1 gene polymorphisms in susceptibility to myocardial infarction, including early-onset and recurrent MI, in Russians was unclear.
Are TGFB1 gene polymorphisms associated with increased susceptibility to myocardial infarction in a Russian population?
Case-Control (n=604)
Are TGFB1 gene polymorphisms associated with increased susceptibility to myocardial infarction in a Russian population?
Odds Ratio: 1.45 (95% CI 1.02–2.06)
p-value: p=0.046
Polymorphisms in the TGFB1 gene (-509C>T, 869T>C, 915G>C) are significantly associated with increased susceptibility to myocardial infarction, including early-onset and recurrent MI, in a Russian population.
Hypothesis-generating for TGFB1 in MI susceptibility; leaves open clinical utility pending replication.
Carriage frequencies of alleles and genotypes of theTGFB1 gene polymorphous loci -509C>T (rs1800469), 869T>C (rs1982073), 915G>C (rs1800471), which affect the level of cytokine TGF-β1 production, were analyzed in the patients of Russian ethnic descent with myocardial infarction (MI) (406 cases) and in the control group of the same ethnic descent (198 controls). Significant association with MI was observed in carriage frequencies of the alleleTGFB1*-509T (p=0.046, OR =1.45, 95% CI: 1.02-2.06), genotypes TGFB1*869T/T (p=0.0024, OR =1.75, 95% CI: 1.22-2.51), andTGFB1*915G/G (p=0.048, OR=1.76, 95% CI: 1.05-2.97). Linkage disequilibrium analysis for these SNPs has shown that the associations revealed can be considered to be independent. A complex analysis of MI association with combinations of alleles/genotypes of said SNPs indicates their cumulative effect. An analysis of susceptibility to early-onset MI (≤ 50 years old) revealed a positive association of the alleleTGFB1*-509T (p=0.002, OR=2.24, 95% CI: 1.35-3.71) and genotypeTGFB1*869T/T (p=0.008, OR=1.93, 95% CI: 1.18-3.15), as well as their additivity. An analysis of susceptibility to recurrent MI revealed an association of the genotypeTGFB1*-509T/T (p=0.0078, OR=2.60, 95% CI: 1.28-5.28). The results obtained indicate the important role of theTGFB1gene in susceptibility to MI, including early-onset and recurrent MI, in Russians.
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Барсова et al. (2012) conducted a case-control in Myocardial infarction (n=604). TGFB1 gene polymorphisms (-509C>T, 869T>C, 915G>C) vs. Controls without myocardial infarction was evaluated on Myocardial infarction (association with allele TGFB1*-509T) (OR 1.45, 95% CI 1.02-2.06, p=0.046). Carriage of the TGFB1*-509T allele was significantly associated with increased susceptibility to myocardial infarction (OR 1.45; 95% CI 1.02-2.06; p=0.046).
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