Key result
Cold exposure at 4°-5°C increased proliferation in the endothelium and extravascular fat precursor cells of interscapular brown fat in six-week-old rats, a process requiring intact innervation.
Population
Rats (six weeks old and seven months old)
Comparison
Cold exposure at 4°–5°C vs Normal temperature or denervated side of…
Design
Preclinical
Follow-up
Up to 8 days
Authors
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Hypothesis-generating for neural BAT regulation in young rats; human translation and therapeutic relevance remain untested.
Cold exposure induces rapid, nerve-dependent cellular proliferation in the vascular and precursor cells of brown adipose tissue in young rats.
Hunt et al. (1967) studied this question. Cold exposure (4°-5°C) vs. Normal temperature (23°C) or denervated tissue was evaluated on Proliferation in brown fat (endothelium and extravascular fat precursor cells). Cold exposure at 4°-5°C increased proliferation in the endothelium and extravascular fat precursor cells of interscapular brown fat in six-week-old rats, a process requiring intact innervation.
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