Key result
Sublingual nifedipine did not affect left ventricular regional wall motion during exercise in hypertensive patients without CAD, but induced significant changes in 7 of 14 patients with CAD.
Why the study?
Does rapid blood pressure normalization with sublingual nifedipine alter left ventricular ejection fraction and regional wall motion during exercise in hypertensive patients with and without coronary artery disease?
Population
35 patients with mild to moderate hypertension undergoing coronary angiography for the evaluation of chest…
Comparison
Sublingual nifedipine administered 1 hour before… vs Upright bicycle exercise echocardiography…
Design
Cohort
Follow-up
1 day
Authors
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May warrant caution with sublingual nifedipine in CAD patients; leaves open need for randomized safety data during exercise.
Does rapid blood pressure normalization with sublingual nifedipine alter left ventricular ejection fraction and regional wall motion during exercise in hypertensive patients with and without coronary artery disease?
Rapid blood pressure decrease with nifedipine does not alter exercise LV dynamics in hypertensives without CAD, but can induce variable changes in wall motion in those with significant coronary stenoses.
Mauro Pepi (1997) studied Hypertension and suspected coronary artery disease (n=35). Sublingual nifedipine vs. Without therapy (baseline) was evaluated on Left ventricular ejection fraction and regional wall motion scores during exercise. Sublingual nifedipine did not affect left ventricular regional wall motion during exercise in hypertensive patients without CAD, but induced significant changes in 7 of 14 patients with CAD.
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