Key result
Higher 18F-FDG uptake on PET/CT independently predicted an unfavorable outcome, including rupture and progression, in medically treated acute aortic dissection (OR 7.72; 95% CI 1.44-41.4; P=0.0171).
Why the study?
Does 18F-FDG PET/CT uptake predict unfavorable outcomes in medically treated acute aortic dissection patients?
Observational (n=28)
Does 18F-FDG PET/CT uptake predict unfavorable outcomes in medically treated acute aortic dissection patients?
Odds Ratio: 7.72 (95% CI 1.44–41.4)
p-value: p=0.0171
Increased 18F-FDG uptake on PET/CT in acute aortic dissection is significantly associated with an increased risk for rupture, surgical repair, and progression.
May refine risk stratification in medically managed aortic dissection; hypothesis-generating and needs prospective validation.
UNLABELLED: Imaging with (18)F-FDG PET/CT is able to reveal vascular inflammation, and several studies have shown that increased (18)F-FDG uptake in carotid artery plaques can qualify the degree of atherosclerotic inflammation. However, clinical assessment of acute aortic dissection (AAD) by PET/CT remains largely unexplored. This study aimed to investigate the use of (18)F-FDG PET/CT to predict short- and midterm outcomes in medically controlled AAD patients. METHODS: A total of 28 medically treated AAD patients (2 Stanford type A and 26 type B, aged 69.5 +/- 11.6 y) were prospectively studied. All patients were examined by enhanced CT for diagnosis of AAD and underwent serial imaging studies during follow-up. PET/CT images were acquired 50 and 100 min after (18)F-FDG injection in all patients in the acute phase. RESULTS: Of the 28 patients, 8 who had an unfavorable outcome due to death from rupture (n = 2), surgical repair (n = 4), and progression of dissection (n = 2) were categorized as having unfavorable AAD. The remaining 20 patients were categorized as having favorable AAD. Maximum dissection diameter in the unfavorable group was significantly greater than that in the favorable group (P = 0.0207). On 50-min images, maximal and mean standardized uptake values (SUVs) at maximum aortic dissection sites were significantly greater for the unfavorable group than for the favorable group (all P < 0.01). A stepwise-forward selection procedure demonstrated that the mean SUV at sites of maximum aortic dissection on 50-min images significantly and independently predicted an unfavorable outcome for AAD (P = 0.0171; odds ratio, 7.72; 95% confidence interval, 1.44-41.4; R(2) = 0.2372). A mean SUV greater than 3.029 had significant predictive power, with sensitivity of 75.0%, specificity of 70.0%, a positive predictive value of 50.0%, a negative predictive value of 87.5%, and accuracy of 71.4%. CONCLUSION: Greater uptake of (18)F-FDG in AAD was significantly associated with an increased risk for rupture and progression. (18)F-FDG PET/CT may be used to improve AAD patient management, although more studies are still needed to clarify its role in this clinical scenario.
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Kato et al. (2010) conducted an observational in Acute aortic dissection (n=28). 18F-FDG PET/CT uptake (mean SUV) vs. Lower 18F-FDG uptake was evaluated on Unfavorable outcome (death from rupture, surgical repair, and progression of dissection) (OR 7.72, 95% CI 1.44-41.4, p=0.0171). Higher 18F-FDG uptake on PET/CT independently predicted an unfavorable outcome, including rupture and progression, in medically treated acute aortic dissection (OR 7.72; 95% CI 1.44-41.4; P=0.0171).
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