Key result
Significant FDG uptake in the aneurysm wall before EVAR was associated with a higher rate of type II endoleaks during the first year (83.3% vs 27.3%, p=0.04).
Why the study?
To evaluate whether aortic 18F-FDG uptake on PET/CT could help predict complications following endovascular aneurysm repair.
Does 18F-FDG PET/CT predict post-EVAR complications in men with abdominal aortic aneurysms?
Cohort (n=51)
Does 18F-FDG PET/CT predict post-EVAR complications in men with abdominal aortic aneurysms?
Absolute Event Rate: 83.3% vs 27.3%
p-value: p=0.04
18F-FDG PET/CT imaging of the aortic wall before or after EVAR may help identify patients at high risk for complications such as type II endoleaks and sac growth.
Purpose: To assess if aortic 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography/computed tomography (PET/CT) could play a role in predicting complications after endovascular aneurysm repair (EVAR). Materials and Methods: This study involved 2 cohorts of men with abdominal aortic aneurysm treated by EVAR: those who underwent a PET/CT scan before EVAR (n=17) and those who had a PET/CT during follow-up (n=34). Uptake of FDG was measured as the standardized uptake value (SUV). D-dimer, a marker of fibrinolysis, was measured in blood drawn concomitantly with the PET/CT. Results: A significant uptake of FDG in the aneurysm wall was detected by PET/CT before EVAR in 6 of 17 patients. During the first year after EVAR, type II endoleaks developed in 5 of these FDG+ patients vs 3 of 11 FDG– patients (p=0.04). Two of the FDG+ patients had continued sac growth and required conversion to open repair. A significant association between sac growth rate, SUV, and the presence of endoleak was found in the 34 patients who underwent PET/CT after EVAR. Finally, D-dimer was significantly increased in patients with both endoleak and positive PET/CT in the post-EVAR group. Conclusion: This study suggests that the presence of FDG uptake in the aortic wall might be a useful tool to predict patients at high risk of developing post-EVAR complications.
No takes yet. Share an insight, caveat, or question.
Courtois et al. (2019) conducted a cohort in Abdominal aortic aneurysm (n=51). Aortic 18F-fluorodeoxyglucose (FDG) uptake on PET/CT vs. No significant FDG uptake was evaluated on Development of type II endoleaks during the first year after EVAR (p=0.04). Significant FDG uptake in the aneurysm wall before EVAR was associated with a higher rate of type II endoleaks during the first year (83.3% vs 27.3%, p=0.04).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: