Key result
Post-TAVR 18F-FDG uptake inversely correlates with left-ventricular mass index.
Why the study?
The relationship between pre-discharge 18F-FDG-PET/CT uptake pattern following TAVR and adverse prognostic features of aortic stenosis was not known.
Observational (n=12)
18F-Flourodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) has been shown to be of utility in transcatheter aortic valve replacement (TAVR) patients with suspected prosthetic valve endocarditis. In the present study, we sought to analyze the relationship between 18F-FDG-PET/CT performed before discharge in TAVR patients and adverse prognostic features of aortic stenosis. We analyzed the association between 18F-FDG-PET/CT uptake pattern and degree of left ventricular mass index, aortic root dilatation, and aortic leaflet calcification extent. This is the first study to demonstrate that pre-discharge 18F-FDG-PET/CT in patients undergoing TAVR shows a significant negative correlation between 18F-FDG uptake pattern and adverse prognostic features.
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Chandrasekar et al. (2023) conducted an observational in Severe degenerative aortic stenosis post-TAVR (n=12). 18F-FDG-PET/CT uptake pattern vs. Extensive vs limited uptake pattern was evaluated on Correlation of 18F-FDG uptake pattern with left-ventricular mass index (r = -0.69, p=0.01). Pre-discharge 18F-FDG uptake pattern following TAVR demonstrated a significant negative correlation with adverse prognostic features, including increased left-ventricular mass index (r = -0.69).
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