Why the study?
Does real time cross-sectional echo contrast using peripheral venous injection of dextrose 5% in water accurately detect and localize right-to-left shunts in adult patients?
Does real time cross-sectional echo contrast using peripheral venous injection of dextrose 5% in water accurately detect and localize right-to-left shunts in adult patients?
Peripheral venous injection of 5% dextrose in water for real-time cross-sectional echo contrast is highly specific, as no contrast was detected in the left heart of control patients without shunts.
Answers are grounded in this paper and cite their sources.
Supports high specificity of echo contrast for right-to-left shunts; leaves open prospective validation of sensitivity and localization.
The usefulness of performing real time cross-sectional echo contrast studies, using peripheral venous injections ofdextrose 5 per cent in water, for the detection and localisation of atrial and ventricular right-to-left shunts was evaluated in 70 adult patients. Based on their catheterisation data, 20 patients had a shunt at atrial level (group 1) and 14 patients a ventricular septal defect (group 2). Thirty-six patients without a shunt by oximetry served as controls. Echo contrast could not be detected in the left-sided cardiac cavities in any of the control patients.
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Serruys et al. (1979) studied this question.
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