Experimental Encephalomyelitis: Its Relation to Disseminated Sclerosis¹

Summary Experimental allergic encephalomyelitis was produced in guinea‐pigs, rabbits and ferrets, whilst an attempt in mice was not successful. The clinical and histological responses in these groups of animals differed, and in the animals with a more highly developed central nervous system the lesions were more demyelinating in character. A combination of intracerebral injection of herpes simplex virus and experimental allergic encephalomyelitis, in ferrets, produced demyelination resembling that seen in disseminated sclerosis. A similar procedure carried out in guinea‐pigs was unsuccessful.