Key result
Injection of autologous brain tissue incorporated with adjuvants successfully produced acute disseminated encephalomyelitis in rhesus monkeys.
Why the study?
Does injection of autologous brain tissue with adjuvants produce acute disseminated encephalomyelitis in rhesus monkeys?
Does injection of autologous brain tissue with adjuvants produce acute disseminated encephalomyelitis in rhesus monkeys?
Demonstrates an experimental model for acute disseminated encephalomyelitis in rhesus monkeys using autologous brain tissue.
Offers primate ADEM model for mechanistic work; leaves open translation to human disease.
Acute disseminated encephalomyelitis has been produced in rhesus monkeys by injection of their own brain tissue, removed surgically and incorporated with adjuvants.
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Kabat et al. (1949) studied this question. Injection of autologous brain tissue incorporated with adjuvants successfully produced acute disseminated encephalomyelitis in rhesus monkeys.
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