Key result
Stimulation of alpha-adrenergic receptors increased systemic capacitance vessel tone, while beta-adrenergic stimulation decreased tone only when previously elevated by angiotensin-II in dogs.
Why the study?
Does the infusion of alpha and beta adrenergic receptor stimulants alter the mean circulatory pressure in anesthetized dogs?
Population
Anesthetized, open-chest dogs
Design
Preclinical
Authors
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Animal data on adrenergic capacitance vessel effects require cautious interpretation; leaves open translation to human cardiovascular regulation.
Does the infusion of alpha and beta adrenergic receptor stimulants alter the mean circulatory pressure in anesthetized dogs?
This study demonstrates that alpha-adrenergic stimulation induces venoconstriction, whereas beta-adrenergic stimulation induces venodilation only under conditions of pre-elevated venous tone.
Hirakawa et al. (1984) studied Anesthetized, open-chest dogs. Alpha-adrenergic (phenylephrine) and beta-adrenergic (isoproterenol) receptor stimulants was evaluated on Mean circulatory pressure (MCP). Stimulation of alpha-adrenergic receptors increased systemic capacitance vessel tone, while beta-adrenergic stimulation decreased tone only when previously elevated by angiotensin-II in dogs.
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