Key result
The need for extracorporeal membrane oxygenation in acute myocarditis was associated with a significantly higher risk of cardiovascular death (HR 3.88) compared to no mechanical support, primarily within 3 months.
Why the study?
Does mechanical circulatory support (ECMO or IABP) affect long-term cardiovascular death or heart failure hospitalization in adult survivors of acute myocarditis requiring intensive care?
Population
1,145 adults admitted to an intensive care unit due to acute myocarditis, mean age 40.2, 59.3% male…
Comparison
Mechanical circulatory support with either… vs No mechanical circulatory support during…
Design
Cohort
Follow-up
up to 14 years
Authors
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Early CV death risk rises with ECMO need in acute myocarditis; leaves open whether support modifies outcomes beyond marking severity.
Cohort (n=1,145)
Yes
Does mechanical circulatory support (ECMO or IABP) affect long-term cardiovascular death or heart failure hospitalization in adult survivors of acute myocarditis requiring intensive care?
Hazard Ratio: 3.88 (95% CI 2.93–5.12)
Absolute Event Rate: 21.8% vs 12.9%
p-value: p=<0.001
In adult survivors of acute myocarditis requiring intensive care, the need for mechanical circulatory support (indicating greater initial severity) is associated with increased cardiovascular mortality within the first 3 months after discharge, but long-term outcomes are similar to those not requiring support.
Chang et al. (2017) conducted a cohort in Acute myocarditis requiring intensive care treatment (n=1,145). Extracorporeal membrane oxygenation (ECMO) vs. No mechanical circulatory support (Non-MCS) was evaluated on Cardiovascular death (HR 3.88, 95% CI 2.93-5.12, p=<0.001). The need for extracorporeal membrane oxygenation in acute myocarditis was associated with a significantly higher risk of cardiovascular death (HR 3.88) compared to no mechanical support, primarily within 3 months.
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