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August 1, 1980Science155 citations

Vascular Permeation of Platelet Factor 4 After Endothelial Injury

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IGItzhak D. GoldbergMSMichael B. StemermanRHRobert I. Handin

Key Points

  • The aim is to investigate the permeation of platelet factor 4 into blood vessel walls following endothelial injury.
  • Used antibody to platelet factor 4 to detect its presence in vessel walls after endothelial removal in rabbits.
  • Performed immunofluorescence at 10, 30, and 240 minutes post-injury to assess antigen presence.
  • Platelet factor 4 antigen detected in vessel walls at 10 and 30 minutes post-injury, but not at 240 minutes.
  • Demonstrated that platelet-derived factors can enter vessel walls after endothelial injury.
  • Highlighted that the permeation process is short-lived and self-limiting.

Abstract

Antibody to platelet factor 4 was used to demonstrate permeation of this factor into the blood vessel wall after endothelial injury in rabbits. The presence of platelet factor 4 antigen in the vessel wall after removal of the endothelium was shown by immunofluorescence 10 and 30 minutes after injury but not 240 minutes afterward. This study demonstrates that factors carried by platelets can enter the vessel wall and that the movement of these platelet products into the vasculature is a short-lived, self-limiting process.

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Cite This Study

Goldberg et al. (1980) studied this question.

synapsesocial.com/papers/6a21bce05f36377271c63ce8https://doi.org/10.1126/science.6994228
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  4. 4Thrombogenesis of the rabbit arterial plaque. An electron microscopic study.1973 · 79 citations
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