Key result
Platelet factor 4 (PF4) directly bound to oxidized LDL and increased its binding to vascular cells and macrophages, causing an approximately 10-fold increase in ox-LDL esterification by macrophages.
Population
Vascular wall cells, macrophages, and atherosclerotic lesions
Comparison
Platelet factor 4 (PF4) vs Absence of PF4, or cells lacking…
Design
Preclinical
Authors
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May identify PF4 as an atherosclerosis target in models; leaves open translation and therapeutic relevance in humans.
Effect estimate: approximately 10-fold increase
PF4 promotes the accumulation of deleterious lipoproteins by enhancing ox-LDL binding to vascular cells and macrophages, offering a potential pharmacological target for atherosclerosis.
Nassar et al. (2003) studied Atherosclerosis. Platelet Factor 4 (PF4) was evaluated on Binding of ox-LDL to vascular cells and macrophages and accumulation of cholesterol esters (approximately 10-fold increase). Platelet factor 4 (PF4) directly bound to oxidized LDL and increased its binding to vascular cells and macrophages, causing an approximately 10-fold increase in ox-LDL esterification by macrophages.
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