Key result
Large pre-depolarizations and repetitive depolarizations facilitated Ca2+ currents by dramatically increasing the opening probability of the 27 pS Ca2+ channel in bovine chromaffin cells.
Population
Bovine chromaffin cells
Comparison
Depolarizations vs Baseline holding potentials without…
Design
Preclinical
Authors
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Does not inform clinical Ca2+ channel management; leaves open applicability to human cardiovascular cells.
Bovine chromaffin cells possess three distinct types of Ca2+ channels, with the 27 pS channel uniquely exhibiting facilitation (increased opening probability) following depolarizations.
Artalejo et al. (1991) studied Bovine chromaffin cell Ca2+ channels. Pre-depolarizations was evaluated on Ca2+ channel opening probability and whole-cell currents. Large pre-depolarizations and repetitive depolarizations facilitated Ca2+ currents by dramatically increasing the opening probability of the 27 pS Ca2+ channel in bovine chromaffin cells.
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