Key result
Large depolarizations and the dihydropyridine BAY K 8644 induce long-duration openings of voltage-dependent calcium channels in bovine adrenal chromaffin cells, indicating multiple open states.
Population
Bovine adrenal chromaffin cells from calves, maintained in culture up to 14 days.
Comparison
Depolarizing pulses to various voltages and… vs Less positive voltages or absence of BAY K 8644
Design
Preclinical
Authors
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Indicates multiple open states in bovine Ca channels; challenges single-state models but leaves open human cardiac relevance.
Voltage-dependent calcium channels in adrenal chromaffin cells exhibit multiple open states, challenging the traditional single open-state model.
Hoshi et al. (1987) studied None (In vitro study). Large depolarization and BAY K 8644 vs. Small depolarization / control was evaluated on Calcium channel open time duration. Large depolarizations and the dihydropyridine BAY K 8644 induce long-duration openings of voltage-dependent calcium channels in bovine adrenal chromaffin cells, indicating multiple open states.
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