Key result
Stimulation-dependent facilitation of the high threshold calcium current in guinea-pig ventricular myocytes is mediated by calcium and modulated by isoprenaline and caffeine.
Population
Guinea-pig ventricular myocytes
Comparison
Electrical stimulation and pharmacological… vs Baseline/rest conditions
Design
Preclinical
Authors
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No direct clinical implications; leaves open relevance of calcium-mediated facilitation to human ventricular myocytes.
Stimulation-dependent facilitation of high threshold calcium currents in ventricular myocytes is mediated by calcium, likely through modulation of a phosphorylation step.
Zygmunt et al. (1990) studied this question. Electrical stimulation and pharmacological agents (isoprenaline, caffeine) vs. Rest/baseline was evaluated on Facilitation of the high threshold calcium current. Stimulation-dependent facilitation of the high threshold calcium current in guinea-pig ventricular myocytes is mediated by calcium and modulated by isoprenaline and caffeine.
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