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November 1, 1988The Journal of PhysiologyOpen Access

Mechanism of the use dependence of Ca2+ current in guinea‐pig myocytes.

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Authors

David FedidaDavid FedidaElectrophysiologyDNDenis NobleElectrophysiologyASA J SpindlerUniversity of Oxford

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Implication

Randomized trial examines calcium current dynamics in guinea-pig myocytes, suggesting implications for calcium handling.

Key Points

  • To investigate the mechanisms behind the use-dependent changes in calcium current in guinea-pig myocytes.
  • Varied extracellular calcium concentration ([Ca2+]o) and intracellular calcium concentration ([Ca2+]i) while measuring calcium current (iCa) in single myocytes.
  • Examined the effects of internal calcium buffering with EGTA and external Ba2+ substitution on iCa dynamics.
  • Analyzed the impact of reducing extracellular sodium concentration ([Na+]o) on iCa and use-dependent variations.
  • Moderate increases in [Ca2+]i and changes in [Ca2+]o enhance the use-dependent reduction of iCa.
  • Intracellular calcium overload significantly reduces iCa and negates use-dependent changes.
  • Replacing Ca2+ with Ba2+ decreases use-dependent reduction and the facilitation of iCa, especially when internal calcium is buffered.

Cite This Study

Fedida et al. (1988) studied this question.

synapsesocial.com/papers/6a21c73f7cd64f3298c00a83https://doi.org/10.1113/jphysiol.1988.sp017342
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Use‐dependent reduction and facilitation of Ca2+ current in guinea‐pig myocytes.1988 · 54 citations
  2. 2An intrinsic potential‐dependent inactivation mechanism associated with calcium channels in guinea‐pig myocytes.1987 · 134 citations
  3. 3Effects of various intracellular Ca ion concentrations on the calcium current of guinea-pig single ventricular cells.1984 · 51 citations
  4. 4Inward current related to contraction in guinea‐pig ventricular myocytes.1987 · 87 citations
  5. 5Potentiation of the calcium-channel currents of internally perfused mammalian heart cells by repetitive depolarization.1987 · 112 citations