Key result
Central arterial stiffness (c-fPWV ≥ 7.6 m/s) or medication use was associated with higher central systolic pressure compared to healthy vascular aging (111-112 vs 99 mmHg, P<0.05).
Why the study?
Central arterial stiffness and healthy vascular aging had not been adequately evaluated in elderly patients with optimal or normal blood pressure levels.
Cross-Sectional (n=102)
p-value: p=< 0.05
Older individuals with optimal peripheral blood pressure may still exhibit central arterial stiffness and lack healthy vascular aging.
Central stiffness may raise central pressures despite optimal peripheral BP in older adults; leaves open whether stiffness assessment improves risk stratification.
INTRODUCTION: Pulse wave velocity is used to diagnose central arterial stiffness (CAS) and quantify healthy vascular aging (HVA). OBJECTIVE: To evaluate the CAS and HVA in elderly patients with systemic blood pressure levels classified as optimal/normal. METHODS: A total of 102 patients without comorbidities and with systolic pressure (SP) < 120 mmHg and diastolic pressure (DP) < 80 mmHg were selected from the EVOPIU database (Pulse Wave Velocity of Elderly Individuals in an Urban area of Brazil). The carotid-femoral pulse wave velocity (c-fPWV) and the central and peripheral pressures were evaluated in all patients. The patients were divided into four groups: G1: (n = 19, with c-fPWV < 7.6 m/s, without medication), G2 (n = 26, c-fPWV ≥ 7.6 m/s; without medication), G3 (n = 25, c-fPWV < 7.6 m/s with antihypertensive medication), and G4 (n = 32, c-fPWV ≥ 7.6 m/s with antihypertensive medication). RESULTS: In our sample, 56.7% of patients had c-fPWV ≥ 7.6 m/s. The central systolic pressure in G1 [99 (10) mmHg] was lower than that found in the other three groups [vs. 112 (14) mmHg, 111 (15), 112 (20) mmHg; P < 0.05)]. CONCLUSION: Older people with optimal arterial blood pressure do not necessarily have HVA and could have c-fPWV values close to the limits established for CAS diagnosis.
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Jiticovski et al. (2023) conducted a cross-sectional in Optimal blood pressure (n=102). Central arterial stiffness (c-fPWV ≥ 7.6 m/s) and/or antihypertensive medication use vs. c-fPWV < 7.6 m/s without medication was evaluated on Central systolic pressure (p=< 0.05). Central arterial stiffness (c-fPWV ≥ 7.6 m/s) or medication use was associated with higher central systolic pressure compared to healthy vascular aging (111-112 vs 99 mmHg, P<0.05).
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