Key result
Advanced age (>80 years) in hypertensive patients was associated with significantly higher pulse wave velocity (18.7 vs 15.8 m/s, p<0.05) and cardio-ankle vascular index compared to patients <80 years.
Why the study?
Do peripheral artery properties measured by non-invasive oscillometry differ between elderly (<80 years) and very elderly (>80 years) hypertensive patients?
Cross-Sectional (n=89)
Do peripheral artery properties measured by non-invasive oscillometry differ between elderly (<80 years) and very elderly (>80 years) hypertensive patients?
Absolute Event Rate: 18.7% vs 15.8%
p-value: p=<0.05
Age is significantly correlated with increased arterial stiffness as measured by pulse wave velocity and cardio-ankle vascular index in elderly hypertensive patients.
Suggests greater arterial stiffness in very elderly hypertensives; leaves open whether PWV/CAVI improve risk prediction.
To evaluate peripheral arteries properties in hypertensive elderly and very elderly patients with non-invasive oscillometric technique. In 89 hypertensive patients >60 years (35 of them were >80 years) pulse wave velocity (PWV), cardio-ankle vascular index (CAVI) and ankle-brachial index (ABI) were measured with vascular screening system VS 1000 (Fukuda Denshi, Japan). The VS 1000 provides blood pressure (BP) and plethysmograms measurements on four limbs and simultaneous registration of phono- and electrocardiograms. CAVI is a new index independent from BP level. The data are shown as Mean±SD. Student t-test was used for group comparison. Spearmen analysis was used to evaluate correlation between vascular characteristics and age. p<0,05 was considered significant. BP level was similar in the patients <80 and >80 years (146,0±17,4/84,8±10,3 and 149,0±15,2/82,1±8,3 mmHg respectively). In patients <80 years PWV was15,8±4,6 m/s, in those >80 years 18,7±4,4 m/s (p<0,05) (evaluated upper normal range 13,5 m/s), CAVI 9,7±2,4 and 11,5±3,8 respectively (p<0,05), ABI 1,0±0,19 and 1,0±0,18 respectively. Positive significant correlation between PWV and age (r=0,34), CAVI and age (r=0,39) was revealed. No significant correlation between ABI and age was found. The results obtained suggest relationship between age and peripheral arteries status assessed by PWV and CAVI, but not by ABI. VS 1000 (Fukuda Denshi, Japan) provides rather quick and easily implemented non-invasive assessment of important indexes of peripheral arteries status.
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KOTOVSKAYA et al. (2005) conducted a cross-sectional in Hypertension (n=89). Age >80 years vs. Age <80 years was evaluated on Pulse wave velocity (PWV) (p=<0.05). Advanced age (>80 years) in hypertensive patients was associated with significantly higher pulse wave velocity (18.7 vs 15.8 m/s, p<0.05) and cardio-ankle vascular index compared to patients <80 years.
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