Key result
Increasing degree of nephropathy in insulin-dependent diabetic patients was significantly associated with increasing attenuation of 24-h cardiac vagal activity (P<0.001).
Why the study?
Is 24-h cardiac parasympathetic activity associated with the degree of nephropathy in insulin-dependent diabetic patients?
Cross-Sectional (n=51)
Is 24-h cardiac parasympathetic activity associated with the degree of nephropathy in insulin-dependent diabetic patients?
p-value: p=<0.001
Reduced 24-h vagal activity is associated with increasing degrees of nephropathy in insulin-dependent diabetic patients, suggesting a common pathogenetic mechanism and potential risk for cardiac death.
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May flag cardiac risk in IDDM nephropathy; hypothesis-generating for shared pathogenesis, needing longitudinal confirmation.
Mølgaard et al. (1992) conducted a cross-sectional in Insulin-dependent diabetes mellitus (n=51). Degree of nephropathy vs. Healthy control subjects was evaluated on 24-h cardiac parasympathetic (vagal) activity (p=<0.001). Increasing degree of nephropathy in insulin-dependent diabetic patients was significantly associated with increasing attenuation of 24-h cardiac vagal activity (P<0.001).
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