What question did this study set out to answer?

This research investigates how plasma renin activity and aldosterone levels relate to hemodynamic functions in men with essential hypertension.

August 1, 1977Archives of Internal Medicine

Relationship of Plasma Renin Activity and Aldosterone Levels With Hemodynamic Functions in Essential Hypertension

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Population

47 male patients with untreated, permanent essential hypertension, normal creatinine clearance, receiving a…

Design

Cross-sectional

Authors

GLGérard M. LondonVascular Medicine

Discussion

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Implication

These correlations should not change practice; leaves open renin-aldosterone contributions to hemodynamics in hypertension.

Key Points

This research investigates how plasma renin activity and aldosterone levels relate to hemodynamic functions in men with essential hypertension.
Analyzed plasma renin activity and aldosterone levels in 47 untreated male patients with essential hypertension.
Subjects followed a controlled diet of 110 mEq/day of sodium and underwent hemodynamic measurements.
Examined correlations between renin and aldosterone levels and various cardiovascular indices.
Supine plasma renin activity positively correlated with cardiac index (P<.01) and cardiopulmonary blood volume (P=.01).
Percentage changes in plasma renin activity and total peripheral resistance while upright strongly correlated (P<.001).
Supine plasma aldosterone level correlated positively with stroke index (P<.001) and negatively with heart rate (P<.05).

Structured PICO

Population

47 male patients with untreated, permanent essential hypertension, normal creatinine clearance, receiving a diet of 110 mEq/day of sodium.

Outcome

Correlation of plasma renin activity and plasma aldosterone levels with hemodynamic functions (cardiac index, cardiopulmonary blood volume, total peripheral resistance, stroke index, heart rate)surrogate

Plasma renin activity and aldosterone levels correlate with specific hemodynamic parameters in untreated essential hypertension, suggesting neural sympathetic control and a relationship between aldosterone and cardiac performance.

Cite This Study

Gérard M. London (1977) studied this question.

synapsesocial.com/papers/6a21ca0b6bffe688a67c31a4 https://doi.org/10.1001/archinte.1977.03630200048015

Topics

Hypertension management

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Relationship of Plasma Renin Activity and Aldosterone Levels With Hemodynamic Functions in Essential Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Relationship of Plasma Renin Activity and Aldosterone Levels With Hemodynamic Functions in Essential Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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