Key result
Hypertension from sympathetic overactivity in subjects with cervical spinal cord transections caused a rise in plasma dopamine beta-hydroxylase peaking 3 to 5 minutes after peak blood pressure.
Why the study?
Does sympathetic nervous overactivity causing hypertension increase plasma dopamine beta-hydroxylase in subjects with cervical spinal cord transections?
Observational
Does sympathetic nervous overactivity causing hypertension increase plasma dopamine beta-hydroxylase in subjects with cervical spinal cord transections?
Plasma dopamine beta-hydroxylase rises following sympathetic nervous overactivity-induced hypertension, peaking 3-5 minutes after peak blood pressure, highlighting the importance of sample timing.
May warrant timed DBH sampling during autonomic dysreflexia; hypothesis-generating for sympathetic biomarker validation in spinal cord injury.
In subjects with cervical spinal cord transections, hypertension due to sympathetic nervous overactivity resulted in a rise in plasma dopamine beta-hydroxylase (DbetaH), the peak occurring 3 to 5 min after the peak blood pressure response. This indicates that DbetaH may be released from sympathetic nerve terminals during sympathetic activity in man, and emphasizes the importance of sample timing in acute studies on DbetaH.
No takes yet. Share an insight, caveat, or question.
Mathias et al. (1976) conducted an observational in Cervical spinal cord transections with hypertension. Sympathetic nervous overactivity (hypertension) was evaluated on Plasma dopamine beta-hydroxylase (DbetaH) levels. Hypertension from sympathetic overactivity in subjects with cervical spinal cord transections caused a rise in plasma dopamine beta-hydroxylase peaking 3 to 5 minutes after peak blood pressure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: