Key result
Poor metabolic control (HbA1c >7%) in early pregnancy significantly increased the total pregnancy loss rate compared to fair control (22.2% vs. 5.3%; OR 5.1; 95% CI 1.4-17.1).
Why the study?
Does poor metabolic control increase the risk of adverse pregnancy outcomes in women with pregestational diabetes?
Population
126 women with pregestational diabetes
Comparison
Poor metabolic control (early maternal HbA1c >7%) vs Fair metabolic control
Design
Cohort
Follow-up
throughout pregnancy to perinatal period
Authors
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Supports optimizing early glycemic control in pregestational diabetes; leaves open causal confirmation from prospective trials.
Cohort (n=126)
No
Does poor metabolic control increase the risk of adverse pregnancy outcomes in women with pregestational diabetes?
Odds Ratio: 5.1 (95% CI 1.4–17.1)
Absolute Event Rate: 22.2% vs 5.3%
Poor metabolic control in early pregnancy among women with pregestational diabetes significantly increases the risk of spontaneous abortions and congenital defects.
Galindo et al. (2006) conducted a cohort in Pregestational diabetes mellitus (n=126). Poor metabolic control (early maternal HbA1c >7%) vs. Fair metabolic control was evaluated on Total pregnancy loss rate (OR 5.1, 95% CI 1.4-17.1). Poor metabolic control (HbA1c >7%) in early pregnancy significantly increased the total pregnancy loss rate compared to fair control (22.2% vs. 5.3%; OR 5.1; 95% CI 1.4-17.1).
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