What question did this study set out to answer?

This research examines the metabolic differences between high density lipoprotein (HDL) and low density lipoprotein (LDL) in normal human fibroblasts.

July 1, 1977Journal of Lipid ResearchOpen Access

Binding, internalization, and degradation of high density lipoprotein by cultured normal human fibroblasts

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This research examines the metabolic differences between high density lipoprotein (HDL) and low density lipoprotein (LDL) in normal human fibroblasts.
Cultured normal human fibroblasts were exposed to labeled HDL and LDL for comparative binding, internalization, and degradation studies.
The uptake was quantified using radiolabeled lipoproteins and compared to fluid or bulk pinocytosis.
The effects on cholesterol content and sterol biosynthesis were measured post-exposure.
The total uptake rate of LDL was 100-fold greater than bulk pinocytosis, while HDL uptake was only due to fluid pinocytosis.
HDL degradation rates by fibroblasts were higher than natural turnover rates in vivo, indicating potential contributions to HDL catabolism by peripheral tissues.
LDL increased the cholesterol content in fibroblasts and inhibited sterol biosynthesis, whereas HDL had no such effects.

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Implication

Comparative studies reveal varying uptake and degradation rates of HDL and LDL by fibroblasts, suggesting distinct metabolic pathways.

Cite This Study

Miller et al. (1977) studied this question.

synapsesocial.com/papers/6a21cbab033871db2707c83d https://doi.org/10.1016/s0022-2275(20)41660-8

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Binding, internalization, and degradation of high density lipoprotein by cultured normal human fibroblasts

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Discussion

Implication

Cite This Study

Binding, internalization, and degradation of high density lipoprotein by cultured normal human fibroblasts

Key Points

Discussion

Implication

Cite This Study

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