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September 1, 1982Journal of Lipid ResearchOpen Access

Receptor-mediated uptake of hypertriglyceridemic very low density lipoproteins by normal human fibroblasts

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Population

Cultured normal human fibroblasts and very low density lipoproteins isolated from plasma of normal and…

Comparison

Hypertriglyceridemic VLDL (Sf 60-400) vs Normolipemic VLDL and low density lipoproteins

Design

Preclinical

Authors

SGSandra H. GianturcoFBF. BrownAGAntonio M. Gotto

Discussion

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Overview

Hypothesis-generating for LDL receptor role in hypertriglyceridemic VLDL clearance; leaves open human relevance and clinical translation.

Structured PICO

P
Population
Cultured normal human fibroblasts and very low density lipoproteins (VLDL) isolated from plasma of normal and hypertriglyceridemic (types 4 and 5) subjects
I
Intervention
Hypertriglyceridemic VLDL (Sf 60-400)
C
Comparator
Normolipemic VLDL (Sf 60-400) and low density lipoproteins (LDL)
O
Outcome
Binding, internalization, and degradation of radiolabeled lipoproteins by fibroblastssurrogate

Hypertriglyceridemic VLDL, unlike normal VLDL, is taken up by fibroblasts via the LDL receptor pathway, providing mechanistic insight into its role in lipid metabolism.

Cite This Study

Gianturco et al. (1982) studied this question.

synapsesocial.com/papers/6a76a0c84fe2e6ffd8ec0dfdhttps://doi.org/10.1016/s0022-2275(20)38070-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT1951 · 318,663 citations
  2. 2Suppression of 3-hydroxy-3-methylglutaryl-CoA reductase by low density lipoproteins produced in vitro by lipoprotein lipase action on nonsuppressive very low density lipoproteins.1979 · 42 citations
  3. 3Control of 3-Hydroxy-3-Methylglutaryl-CoA Reductase Activity in Cultured Human Fibroblasts by Very Low Density Lipoproteins of Subjects with Hypertriglyceridemia1978 · 106 citations
  4. 4Abnormal suppression of 3‐hydroxy‐3‐methylglutaryl‐CoA reductase activity in cultured human fibroblasts by hypertriglyceridemic very low density lipoprotein subclasses1980 · 41 citations
  5. 5Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteins1978 · 433 citations