Key result
Elevated plasma triglycerides significantly increased the LDL triglyceride weight ratio (0.359 vs 0.126) and altered LDL physical properties and cell-specific binding.
Population
30 normolipidemic subjects and 48 hypertriglyceridemic subjects, plus in vitro models using human hepatoma…
Design
Case-control
Authors
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Triglyceride elevation may modify LDL-cell interactions; hypothesis-generating for atherogenic mechanisms, requires prospective confirmation before clinical consideration.
Case-Control (n=78)
Yes
Absolute Event Rate: 0.359% vs 0.126%
p-value: p=<0.001
Elevated plasma triglycerides predictably alter LDL composition and physical properties, leading to differential receptor-mediated uptake by hepatic versus peripheral cells.
McKeone et al. (1993) conducted a case-control in Hypertriglyceridemia (n=78). Hypertriglyceridemia vs. Normolipidemia was evaluated on LDL triglyceride weight ratio (WR) (p=<0.001). Elevated plasma triglycerides significantly increased the LDL triglyceride weight ratio (0.359 vs 0.126) and altered LDL physical properties and cell-specific binding.
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