What question did this study set out to answer?

This research aims to compare the LDL binding, internalization, and degradation between normal fibroblasts and those from a patient with homozygous familial hypercholesterolemia.

January 1, 1976Proceedings of the National Academy of SciencesOpen Access

Binding, internalization, and degradation of low density lipoprotein by normal human fibroblasts and by fibroblasts from a case of homozygous familial hypercholesterolemia.

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Authors

OSOliver SteinKarlsruhe Institute of Technology DWDavid WeinsteinFlorida State University YSY. SteinBaylor College of Medicine

Discussion

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Implication

Randomized trial compares LDL behavior in fibroblasts from a HFH patient and normal cells, indicating significant defects in internalization.

Key Points

This research aims to compare the LDL binding, internalization, and degradation between normal fibroblasts and those from a patient with homozygous familial hypercholesterolemia.
Skin fibroblasts from a HFH patient were compared with normal fibroblasts.
Binding, internalization, and degradation of iodinated LDL were measured.
Surface binding was assessed at 0 degrees to limit internalization effects.
LFH fibroblasts showed 1-10% internalization of LDL compared to normal cells.
LDL degradation was reduced in HFH cells, but still significant.
Surface binding for HFH cells was slightly less at low LDL concentrations but similar or greater at high concentrations.

Cite This Study

Stein et al. (1976) studied this question.

synapsesocial.com/papers/6a21cbab033871db2707c83e https://doi.org/10.1073/pnas.73.1.14

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January 1, 1976Proceedings of the National Academy of SciencesOpen Access

Binding, internalization, and degradation of low density lipoprotein by normal human fibroblasts and by fibroblasts from a case of homozygous familial hypercholesterolemia.

View Full Paper

Ask AI

Bookmark

Authors

OSOliver SteinKarlsruhe Institute of Technology DWDavid WeinsteinFlorida State University YSY. SteinBaylor College of Medicine

Discussion

Member takes

Implication

Randomized trial compares LDL behavior in fibroblasts from a HFH patient and normal cells, indicating significant defects in internalization.

Key Points

This research aims to compare the LDL binding, internalization, and degradation between normal fibroblasts and those from a patient with homozygous familial hypercholesterolemia.
Skin fibroblasts from a HFH patient were compared with normal fibroblasts.
Binding, internalization, and degradation of iodinated LDL were measured.
Surface binding was assessed at 0 degrees to limit internalization effects.
LFH fibroblasts showed 1-10% internalization of LDL compared to normal cells.
LDL degradation was reduced in HFH cells, but still significant.
Surface binding for HFH cells was slightly less at low LDL concentrations but similar or greater at high concentrations.

Cite This Study

Stein et al. (1976) studied this question.

synapsesocial.com/papers/6a21cbab033871db2707c83e https://doi.org/10.1073/pnas.73.1.14

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