What does this research mean for the field?

Familial HDL deficiency (FHD) is characterized by significantly reduced HDL3- and apoA-I-mediated cellular cholesterol efflux, rather than abnormal cellular HDL3 binding or defects in HDL binding proteins. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1999Arteriosclerosis Thrombosis and Vascular Biology

Cellular Cholesterol Transport and Efflux in Fibroblasts Are Abnormal in Subjects With Familial HDL Deficiency

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Authors

MMMichel MarcilRoyal Victoria Regional Health Centre LYLu YuSichuan University LKLarbi KrimbouMcGill University Health Centre

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Implication

Distinguishes FHD from Tangier disease in low-HDL families; leaves open whether HDL subspecies guide risk stratification or therapy.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Marcil et al. (1999) studied this question.

synapsesocial.com/papers/6a1bd2235b8f4ede65a91aba https://doi.org/10.1161/01.atv.19.1.159

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Cellular Cholesterol Transport and Efflux in Fibroblasts Are Abnormal in Subjects With Familial HDL Deficiency

Discussion

Member takes

Implication

Key Points

Cite This Study

Cellular Cholesterol Transport and Efflux in Fibroblasts Are Abnormal in Subjects With Familial HDL Deficiency

Discussion

Member takes

Implication

Key Points

Cite This Study

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