Key result
2,3-butanedione monoxime (BDM) inhibited Ba2+ currents through human wild-type L-type Ca2+ channels with an IC50 of 16 mM, suggesting it acts via channel block rather than a chemical phosphatase effect.
BDM inhibits calcium channels expressed in Xenopus oocytes likely through direct channel block rather than a chemical phosphatase effect.
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BDM's direct channel block in oocytes cautions against phosphatase assumptions in cardiac models; leaves open in vivo mechanism validation.
Allen et al. (1998) studied this question. 2,3-butanedione monoxime (BDM) was evaluated on Inhibition of Ba2+ currents (IBa) through Ca2+ channels. 2,3-butanedione monoxime (BDM) inhibited Ba2+ currents through human wild-type L-type Ca2+ channels with an IC50 of 16 mM, suggesting it acts via channel block rather than a chemical phosphatase effect.
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