Population
Single guinea-pig cardiac ventricular myocytes and CCL39 fibroblast cells expressing canine NCX1
Design
Preclinical
Authors
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BDM's NCX inhibition in myocytes warrants experimental caution; leaves open intracellular mechanisms beyond phosphatase activity for further study.
BDM inhibits the Na+/Ca2+ exchange current in cardiac myocytes through an intracellular mechanism independent of its 'chemical phosphatase' activity.
Watanabe et al. (2001) studied this question.
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