Key result
Single-channel conductance of L-type calcium channels from failing human ventricles was 16.6 pS under control conditions and increased to 23.7 pS with the calcium-channel agonist FPL 64176.
Population
Ventricular myocytes from explanted failing human hearts (19 cell isolations)
Comparison
Patch-clamp technique with and without… vs Control conditions (no agonist)
Design
Preclinical
Authors
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Patch-clamp recordings feasible in failing human myocytes; leaves open translation to heart failure therapies.
Absolute Event Rate: 23.7% vs 16.6%
Single-channel patch-clamp recordings of L-type calcium channels from failing human ventricular myocytes are feasible and yield properties comparable to mammalian models.
Handrock et al. (1998) studied Heart failure (n=19). FPL 64176 vs. Control conditions was evaluated on Single-channel conductance. Single-channel conductance of L-type calcium channels from failing human ventricles was 16.6 pS under control conditions and increased to 23.7 pS with the calcium-channel agonist FPL 64176.
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