Key result
During acute LAD occlusion in dogs, C-11 palmitic acid clearance halftime was significantly longer in the ischemic borderzone compared to control regions (19±8 vs 10±4 min; p<0.05).
Population
9 closed chest dogs
Comparison
Acute LAD occlusion with serial PET imaging… vs Control regions of the myocardium
Design
Preclinical
Authors
Loading...
Hypothesis-generating for PET detection of borderzone metabolic changes; human studies needed before clinical relevance.
Absolute Event Rate: 19% vs 10%
p-value: p=<0.05
PET imaging demonstrates abnormal free fatty acid metabolism in the borderzone adjacent to ischemic myocardium in a canine model, despite preserved myocardial blood flow.
Schwaiger et al. (1984) studied Acute myocardial ischemia (n=9). Acute LAD occlusion vs. Control myocardial regions was evaluated on C-11 palmitic acid clearance halftime (T 1/2) in minutes (p=<0.05). During acute LAD occlusion in dogs, C-11 palmitic acid clearance halftime was significantly longer in the ischemic borderzone compared to control regions (19±8 vs 10±4 min; p<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: