October 1, 1988Circulation ResearchOpen Access

Fatty acid analogue accumulation: a marker of myocyte viability in ischemic-reperfused myocardium.

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Population

Canine model of ischemia-reperfusion injury

Comparison

Intravenous 15--3-methyl pentadecanoic acid… vs Comparison between TTC positive and TTC negative…

Design

Preclinical

Follow-up

3 hours of reperfusion

Authors

DMDel D. MillerUniversity of Iowa JGJohn B. GillDanaher (United States)ELElijahu LivniHarvard University

Discussion

Member takes

Implication

Fatty acid analogue imaging identifies viable myocardium in animals; leaves open translation to human stunned myocardium assessment.

Structured PICO

Population

Canine model of ischemia-reperfusion injury (n=14 dogs total: 10 in main study with 15- or 60-minute left anterior descending coronary artery occlusion, 4 in SPECT model)

Intervention

Intravenous 15-(para-iodophenyl)-3-methyl pentadecanoic acid (a radioiodinated long chain fatty acid analogue) administered at 3 hours of reperfusion

Comparator

Comparison between TTC positive (viable) and TTC negative (infarcted) myocardial segments

Outcome

Fatty acid analogue activity (percent injected dose per gram) and its ratio to reperfusion blood flowsurrogate

The accumulation of the 15-(para-iodophenyl)-3-methyl pentadecanoic acid analogue noninvasively identifies ischemically stunned but viable myocardium.

Cite This Study

Miller et al. (1988) studied this question.

synapsesocial.com/papers/6a9265479d072e6712f0ceed https://doi.org/10.1161/01.res.63.4.681

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Fatty acid analogue accumulation: a marker of myocyte viability in ischemic-reperfused myocardium.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Fatty acid analogue accumulation: a marker of myocyte viability in ischemic-reperfused myocardium.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider