Key result
Orthostatic hypotension was associated with increased odds of peripheral artery disease (OR 1.49; 95% CI 1.15-1.89), left ventricular hypertrophy, coronary artery disease, and stroke.
Why the study?
Are orthostatic hypertension and orthostatic hypotension associated with cardiovascular disease and target organ damage in hypertensive patients?
Cross-Sectional (n=5,537)
Are orthostatic hypertension and orthostatic hypotension associated with cardiovascular disease and target organ damage in hypertensive patients?
Odds Ratio: 1.49 (95% CI 1.15–1.89)
p-value: p=< 0.01
Both orthostatic hypotension and orthostatic hypertension are associated with increased odds of target organ damage and cardiovascular events, such as peripheral artery disease and stroke, in hypertensive patients.
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May warrant orthostatic assessment in hypertension; hypothesis-generating for prognostic role and requires prospective validation.
Fan et al. (2010) conducted a cross-sectional in Hypertension (n=5,537). Orthostatic hypotension (OH) and orthostatic hypertension (OHT) vs. Normal orthostatic blood pressure response was evaluated on Peripheral artery disease (PAD) (OR 1.49, 95% CI 1.15-1.89, p=< 0.01). Orthostatic hypotension was associated with increased odds of peripheral artery disease (OR 1.49; 95% CI 1.15-1.89), left ventricular hypertrophy, coronary artery disease, and stroke.
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