Key result
Pretreatment of bovine mesenteric arteries with GTN for 2 hours caused significant tolerance to GTN (pD2 4.57 vs 6.96 in controls, P<0.001) and cross-tolerance to endothelium-dependent vasodilators.
Why the study?
Does pretreatment with GTN induce cross-tolerance to other cGMP-mediated vasodilators in bovine mesenteric arteries?
Population
Bovine mesenteric arteries (BMA)
Comparison
Pretreatment with glyceryl trinitrate 0.44 mM… vs Control vessels without pretreatment
Design
Preclinical
Follow-up
2 to 6 hours (incubation time)
Authors
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GTN cross-tolerance to endothelium-dependent vasodilators in bovine arteries; leaves open relevance to human nitrate therapy.
Does pretreatment with GTN induce cross-tolerance to other cGMP-mediated vasodilators in bovine mesenteric arteries?
Absolute Event Rate: 4.57% vs 6.96%
p-value: p=<0.001
GTN induces cross-tolerance to endothelium-dependent vasodilators like acetylcholine and calcium ionophore A23187, but not to atrial natriuretic peptide, in bovine mesenteric arteries.
Ljusegren et al. (1988) studied Vascular smooth muscle tolerance. GTN (glyceryl trinitrate) pretreatment vs. Controls was evaluated on Concentration-effect curve for GTN (pD2) (p=<0.001). Pretreatment of bovine mesenteric arteries with GTN for 2 hours caused significant tolerance to GTN (pD2 4.57 vs 6.96 in controls, P<0.001) and cross-tolerance to endothelium-dependent vasodilators.
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