Why the study?
Patients with significant primary MR can develop LV diastolic dysfunction, but its structural correlates and prognostic significance needed further study.
Does left ventricular diastolic dysfunction predict adverse clinical outcomes in patients with primary mitral regurgitation?
Population
Patients with ≥ moderate primary MR with echocardiographic and CMR scans within a median of 5 days
Comparison
Diastolic dysfunction vs normal diastolic function
Design
Observational cohort study
Key result
A higher left ventricular diastolic dysfunction score was independently associated with an increased risk of cardiovascular death, heart failure hospitalization, or mitral valve surgery (HR 1.39).
Authors
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May enhance risk stratification in primary mitral regurgitation; leaves open need for prospective validation before guiding decisions.
Observational (n=173)
No
Does left ventricular diastolic dysfunction predict adverse clinical outcomes in patients with primary mitral regurgitation?
Hazard Ratio: 1.39 (95% CI 1.14–1.69)
p-value: p=0.001
In patients with primary mitral regurgitation, echocardiographic assessment of left ventricular diastolic dysfunction provides incremental prognostic value for adverse clinical outcomes beyond clinical characteristics and MR severity.
Lababidi et al. (2025) conducted an observational in Primary mitral regurgitation (n=173). Left ventricular diastolic dysfunction score vs. Normal diastolic function was evaluated on Composite of first occurrence of heart failure hospitalization, cardiovascular death, or mitral valve surgery (HR 1.39, 95% CI 1.14-1.69, p=0.001). A higher left ventricular diastolic dysfunction score was independently associated with an increased risk of cardiovascular death, heart failure hospitalization, or mitral valve surgery (HR 1.39).