Key result
Prediabetes is linked to ~1.7 cm/s lower exercise mitral annular early diastolic velocity vs. controls.
Why the study?
The study was conducted to evaluate whether left ventricular diastolic reserve differs between individuals with prediabetes and controls during exercise.
Does prediabetes impair left ventricular diastolic reserve during exercise in asymptomatic adults without overt cardiac disease?
Cross-Sectional (n=100)
No
Does prediabetes impair left ventricular diastolic reserve during exercise in asymptomatic adults without overt cardiac disease?
Absolute Event Rate: 9.42% vs 11.15%
p-value: p=0.001
Exercise stress echocardiography can uncover subclinical left ventricular diastolic dysfunction in prediabetic individuals whose resting echocardiograms appear normal.
Exercise echocardiography may unmask subclinical diastolic impairment in prediabetes; leaves open prognostic value and need for longitudinal validation.
A BSTRACT Objectives: The objective of this study was to evaluate if the diastolic reserve is different in prediabetes versus control during exercise. Materials and Methods: During the resting stage and graded supine bicycling exertion (25 W, 3 min increment), the mitral inflow and septal mitral annular velocities were determined in 50 patients with prediabetes (21 females, mean age 48 ± 16 years) and 50 gender- and age-matched controls. None demonstrated rest or inducible cardiac ischemia on echocardiography. Results: Between the two study groups, the velocities of the mitral inflow (E) and septal mitral annulus (E′) at rest are not significantly different. E′ during exercise, on the other hand, was significantly lower in individuals with prediabetes than in controls (8.57 ± 2.46 vs. 9.82 ± 2.42 cm/s at 25 W, P = 0.012; 9.42 ± 1.93 vs. 11.15±2.97 cm/s at 50 W, P = 0.001). E/E′ behaves oppositely during exercise with a value that is significantly higher in patients with prediabetes. Conclusion: The diastolic reserve of the left ventricle, as determined by the change in E′ and E/E′ throughout exercise, is abnormal in individuals with prediabetes who do not have overt cardiac disease. Using exercise stress echocardiography may be helpful for the early recognition of subclinical diastolic dysfunction in prediabetics which may have clinical repercussions in the future.
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Abdulameer Jasim Jawad Al-Gburi (2022) conducted a cross-sectional in Prediabetes (n=100). Prediabetes vs. Gender- and age-matched normoglycemic controls was evaluated on Mitral annular early diastolic velocity (E') during 50 W exercise (p=0.001). Prediabetes was associated with significantly lower mitral annular early diastolic velocity (E') during 50 W exercise compared to controls (9.42 vs 11.15 cm/s, P = 0.001).
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