Assessment of Left Ventricular Diastolic Reserve in Diabetic Patients by Stress Echocardiography

Background: Patients with type 2 diabetes mellitus (DM) may develop cardiomyopathy independent of traditional risk factors such as hypertension and epicardial coronary artery disease (CAD). The spectrum of myocardial dysfunction may range from subclinical left ventricular (LV) diastolic and systolic dysfunction through to overt systolic dysfunction. Aim and objectives: to determine whether diastolic reserve differs in type 2 DM compared with non-DM, and to identify clinical, anthropological, metabolic and resting echocardiographic correlates of impaired diastolic reserve in patients with DM. Subjects and methods: This study included one hundred consecutive patients (50 patient with DM type II and 50 patient without DM), who underwent rest and exercise echocardiography. Clinical data collected included anthropometric, cardiac risk factors, duration of DM, medications and presence of macrovascular and microvascular complications. Mitral septal é and septal E/é were measured at rest, immediately post, and 10 min into recovery. Results: LDL, cholesterol, triglyceride, creatinine and BMI was significantly higher in in diabetic group than non-diabetic group (P value < 0.05). Regarding rest echocardiography parameters, Septal E/é, Septal é and EF were insignificant between both studied groups. Regarding stress echocardiography parameters, septal E/é was significantly higher and septal é was significantly decreased among diabetic patients among diabetic patients compared to the other group(p