Key result
Asymptomatic T2D shows ~47% lower exercise GLS increase versus controls, indicating impaired LV systolic reserve.
Why the study?
Subclinical LV dysfunction may occur in T2DM patients at the early asymptomatic stage, and LV reserve function is a sensitive index to detect subtle LV dysfunction.
Does treadmill exercise stress echocardiography detect abnormal left ventricular systolic reserve function in asymptomatic type 2 diabetes patients compared to healthy controls?
Cross-Sectional (n=125)
No
Does treadmill exercise stress echocardiography detect abnormal left ventricular systolic reserve function in asymptomatic type 2 diabetes patients compared to healthy controls?
Treadmill exercise stress echocardiography reveals impaired left ventricular systolic reserve function in asymptomatic T2DM patients despite normal resting function, with HbA1c, NT-proBNP, hsCRP, and waist circumference acting as independent predictors.
Answers are grounded in this paper and cite their sources.
May enable earlier detection of subclinical LV impairment in asymptomatic T2DM; leaves open prognostic value and need for prospective validation.
Aims: Subclinical left ventricular (LV) dysfunction may occur in T2DM patients at the early asymptomatic stage, and LV reserve function is a sensitive index to detect subtle LV dysfunction. The purpose of our study is (1) to assess the LV reserve function using treadmill exercise stress echocardiography (ESE) in asymptomatic type 2 diabetes mellitus (T2DM) patients; (2) to explore the link of serum biological parameters and LV reserve function. Methods: This study included 84 patients with asymptomatic T2DM from September 2021 to July 2022 and 41 sex- and age-matched healthy controls during the corresponding period. All subjects completed treadmill ESE, LV systolic function-related parameters such as global longitudinal strain (GLS) and systolic strain rate (SRs), as well as diastolic function-related parameters such as E wave (E), early diastolic velocity (e'), E/e' ratio, early diastolic SR (SRe), and late diastolic SR (SRa) were compared at rest and immediately after exercise. The difference between LV functional parameters after treadmill exercise and its corresponding resting value was used to compute LV reserve function. In addition, the associations of LV reserve function and serum biological parameters were analyzed. Glycated hemoglobin (HbA1c), N-terminal pro-brain natriuretic peptide (NTproBNP), waist circumference, and high-sensitive C-reactive protein (hsCRP) were identified as independent predictors of LV systolic reserve by stepwise multiple linear regression analysis. Conclusion: LV systolic reserve function, as measured by pre- and post-exercise differences in GLS and SRs were significantly impaired in patients with asymptomatic T2DM, whereas diastolic reserve remained normal during exercise and was comparable to that of the control group. This was different from previous findings. High levels of HbA1c, NTproBNP, hsCRP, and increasing waist circumference were independent predictors of LV systolic reserve.
No takes yet. Share an insight, caveat, or question.
Duan et al. (2023) conducted a cross-sectional in Asymptomatic type 2 diabetes mellitus (n=125). Treadmill exercise stress echocardiography vs. Healthy controls was evaluated on Change in global longitudinal strain (ΔGLS) from rest to post-exercise (p=<0.001). In asymptomatic patients with type 2 diabetes, left ventricular systolic reserve function was impaired compared to healthy controls, as evidenced by a lower increase in global longitudinal strain during exercise.
Synapse has enriched 10 related papers. Consider them for comparative context: