What question did this study set out to answer?

To examine how plasma macromolecules transport, interact, and are retained in the intima and their implications for atherogenesis.

Transport, interactions and retention of plasma proteins in the intima: the barrier function of the internal elastic lamina

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Reviews how plasma proteins interact in the intima, affecting atherogenesis and barrier function.

To examine how plasma macromolecules transport, interact, and are retained in the intima and their implications for atherogenesis.
Overview of plasma protein transport mechanisms across normal endothelium and within the intima.
Analysis of molecular size and sieve properties of the internal elastic lamina affecting protein accumulation.
Exploration of modifications of proteins such as HDL and fibrinogen within the intima.
High density lipoprotein undergoes striking modifications within the intima.
Fibrinogen is converted to fibrin, which is subsequently lysed, generating fibrin degradation products.
Association of fibrin with a plasmin-releasable lipoprotein fraction, primarily attributed to lipoprotein(a).

E. B. Smith (1990) studied this question.

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