Key result
Acute myocardial infarction was associated with altered metabolic parameters, with the triglyceride to high-density lipoprotein cholesterol ratio identified as a stable biomarker during recovery.
Why the study?
To explore the interrelationship between acute myocardial infarction and metabolic abnormalities as a pilot project.
Are metabolic abnormalities present at the onset of acute myocardial infarction and do they persist after recovery?
Observational (n=66)
Are metabolic abnormalities present at the onset of acute myocardial infarction and do they persist after recovery?
Metabolic abnormalities, notably an elevated TG/HDL-C ratio, persist after clinical recovery from acute myocardial infarction, suggesting a potential biomarker for high-risk patients.
Objective: To explore the interrelationship, if any, between the acute myocardial infarction and metabolic abnormalities as a pilot project. Methodology: Forty-six acute myocardial infarction patients were selected at the onset and their blood was analysed for some key biochemical parameters. These parameters were analysed again after three weeks in twenty-two patients who recovered and were discharged from the hospital. For comparison, twenty adult individuals were selected as normal controls. Results: Altered glucose and lipid parameters, along with raised serum uric acid & calcium and reduced levels of serum magnesium & potassium, were found during acute myocardial infarction. In the recovery phase, the metabolic changes did not improve in spite of significant clinical improvements. Out of all the parameters, triglyceride / high density lipoprotein cholesterol ratio was found to be a stable biomarker for acute myocardial infarction. Patients with acute myocardial infarction with elevated TG/HDL-C ratio could represent a high-risk group requiring aggressive intervention. Conclusion: Our pilot study indicates that a larger epidemiological study should be conducted in patients with acute myocardial infarction using TG/HDL-C ratio as a biomarker of interest, and finding an appropriate cut-off value for the same.
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Bandopadhyay et al. (2018) conducted an observational in Acute myocardial infarction (n=66). Acute myocardial infarction vs. Normal controls was evaluated on Metabolic abnormalities including glucose, lipid parameters, uric acid, calcium, magnesium, and potassium. Acute myocardial infarction was associated with altered metabolic parameters, with the triglyceride to high-density lipoprotein cholesterol ratio identified as a stable biomarker during recovery.
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