September 1, 1982Clinical Pharmacology & Therapeutics
Changes in ventricular septal thickness during diuretic therapy
Key result
Short-term hydrochlorothiazide therapy in 20 hypertensive patients did not change overall septal thickness, though it decreased in 9 patients and remained unchanged or increased in 11 patients.
Why the study?
Does short-term hydrochlorothiazide therapy alter echocardiographic parameters of left ventricular muscle mass in hypertensive patients?
Population
20 hypertensive patients
Design
Cohort
Follow-up
short-term
Authors
Discussion
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Member takes
Implication
Variable septal response to short-term HCTZ warrants cautious LV mass interpretation; leaves open adaptive remodeling vs true hypertrophy.
Study Design
Type
Observational (n=20)
Structured PICO
Does short-term hydrochlorothiazide therapy alter echocardiographic parameters of left ventricular muscle mass in hypertensive patients?
P
Population
20 hypertensive patients evaluated for changes in echocardiographic parameters during short-term therapy with hydrochlorothiazide.
E
Exposure
Short-term therapy with hydrochlorothiazide
O
Outcome
Changes in echocardiographic parameters of left ventricular muscle mass (septal thickness and posterior wall thickness)surrogate
Increases in left ventricular wall and septal thickness during diuretic therapy likely reflect an adaptive change of cardiac muscle tissue around a smaller left ventricle rather than true hypertrophy.
Cite This Study
Drayer et al. (1982) conducted an observational in Hypertension (n=20). Hydrochlorothiazide was evaluated on Changes in echocardiographic parameters of left ventricular muscle mass (septal and posterior wall thickness). Short-term hydrochlorothiazide therapy in 20 hypertensive patients did not change overall septal thickness, though it decreased in 9 patients and remained unchanged or increased in 11 patients.