Key result
The reserve capacity for ATP consumption was lower for muscle fibers coexpressing MHC(2X) and MHC(2A) (39%) compared with fibers singularly expressing MHC(2A) (52%) and MHC(slow) (56%).
Why the study?
Does the reserve capacity for ATP consumption vary across human vastus lateralis muscle fibers expressing different MHC isoforms?
Population
12 subjects (10 men and 2 women; age 21-66 yr) providing vastus lateralis (VL) muscle biopsies
Comparison
Measurement of V ATPase and ATP consumption rate… vs Comparison across fibers expressing different…
Design
Preclinical
Authors
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Animal fiber data on MHC coexpression and ATP reserve warrant caution in clinical translation; leaves open human vastus lateralis validation.
Cross-Sectional (n=12)
Does the reserve capacity for ATP consumption vary across human vastus lateralis muscle fibers expressing different MHC isoforms?
Fiber-type differences in the reserve capacity for ATP consumption and tension cost reflect functional differences such as susceptibility to fatigue in human skeletal muscle.
Han et al. (2001) reported a cross-sectional. Fibers coexpressing MHC(2X) and MHC(2A) vs. Fibers singularly expressing MHC(2A) and MHC(slow) was evaluated on Reserve capacity for ATP consumption. The reserve capacity for ATP consumption was lower for muscle fibers coexpressing MHC(2X) and MHC(2A) (39%) compared with fibers singularly expressing MHC(2A) (52%) and MHC(slow) (56%).
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