Key result
U-shaped BMI linked to higher hospital-associated disability, with underweight increasing risk ~50%.
Why the study?
Underweight and overweight influence outcomes after cardiovascular surgery, but their effects on hospital-associated disability and hospitalization costs in elective cardiovascular surgery required investigation.
Does body mass index affect hospital-associated disability and hospitalization costs in patients undergoing elective cardiovascular surgery?
Cohort (n=228,891)
Yes
Does body mass index affect hospital-associated disability and hospitalization costs in patients undergoing elective cardiovascular surgery?
Both underweight and obesity are associated with increased hospital-associated disability and higher hospitalization costs in patients undergoing elective cardiovascular surgery.
Extreme BMIs may flag higher HAD risk in elective CV surgery; leaves open whether targeted interventions improve outcomes.
BACKGROUND: Both underweight and overweight are recognized as important factors influencing outcomes in patients undergoing cardiovascular surgery. This study investigated the effects of body mass index (BMI) on hospital-associated disability (HAD) and hospitalization costs in patients undergoing elective cardiovascular surgery (coronary artery bypass grafting, valve surgery, aortic surgery) by analyzing data from the Japanese Registry of All Cardiac and Vascular Diseases - Diagnosis Procedure Combination (JROAD-DPC) database. METHODS AND The prevalence of HAD was 8.7%, with a U-shaped relationship between BMI and HAD, indicating that both extremely low and high BMIs were associated with a higher incidence of HAD. Hospitalization costs also showed a U-shape relationship with BMI, with higher costs for patients with HAD. CONCLUSIONS: Low BMI in any age group was associated with HAD, and older people with a BMI considered too high also had HAD. BMI could be an important risk stratification tool for functional outcomes and economic burden in patients undergoing elective cardiovascular surgery.
No takes yet. Share an insight, caveat, or question.
Ogawa et al. (2025) conducted a cohort in Elective cardiovascular surgery (n=228,891). Body mass index (BMI) vs. Normal weight (BMI 18.5 to <23 kg/m2) was evaluated on Hospital-associated disability (HAD), defined as a decrease of ≥5 points in the Barthel Index from admission to discharge (OR 1.50, 95% CI 1.30-1.73, p=<0.0001). Body mass index exhibited a U-shaped relationship with hospital-associated disability, where both underweight (OR 1.50) and severe obesity (OR 1.22) increased risk compared to normal weight.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: