Why the study?
Does methoxyflurane anesthesia affect renal function compared to halothane in patients undergoing surgical repair of retinal detachment?
Does methoxyflurane anesthesia affect renal function compared to halothane in patients undergoing surgical repair of retinal detachment?
Methoxyflurane anesthesia is associated with subclinical renal impairment (rising creatinine and falling urine osmolality) compared to halothane in patients undergoing non-traumatic surgery.
Methoxyflurane may warrant caution for renal effects in non-traumatic surgery; leaves open causality and need for randomized confirmation.
The surgical repair of retinal detachment was chosen as the operative procedure to use in the investigation of the effects of methoxyflurane on renal function during the first three days after surgery. This was done in order to exclude any additive effect of hypotension, blood loss, or traumatic surgery on the kidney. In this controlled, prospective study, 25 patients received methoxyflurane and 25 received halothane. There was significant rise in the mean serum creatinine level and fall in the mean urine osmolality among patients who received methoxyflurane. No such changes were seen in those given halothane. These data suggest an effect of methoxyflurane on renal function, even when the severe symptomatic syndrome previously described does not occur.
No takes yet. Share an insight, caveat, or question.
R. Merkle (1971) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: